Autoimmune Disease

Conveniently located to serve the areas of New York, NY

Autoimmune Disease Dr. Raphael Kellman New York

Autoimmune disease is a broad range of conditions in which the immune system attacks healthy tissues in the body and the gut microbiome often becomes imbalanced. Autoimmune disease often starts in the gut. When we heal the gut, we can improve the symptoms of your disease. Approximately 50 million Americans are living with autoimmune conditions, (1) and 78% of them are women. (2) More than 80 different conditions—including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Graves’ disease, and Hashimoto’s disease — fall under the umbrella of autoimmune conditions. (3) While most doctors generally view these diseases as separate conditions, they actually all share common causes. When we address these common causes from a natural, functional medicine perspective, we can significantly improve the symptoms of an autoimmune disease.

At Medicine of Tomorrow, Dr. Raphael Kellman determines the best combination of therapies to address your specific needs and symptoms – each protocol is personalized and customized to address your condition and get you back on the road to optimal gut health and immune system healing. In many cases, when he combines these therapeutic modalities, the results are significantly more profound. His expertise in integrating microbiome science into personalized healthcare has set new standards in the field.

Contact our New York office or call (212) 717-1118 to learn more about how we can restore your vitality and improve your quality of life.

About Autoimmune Conditions

Autoimmune diseases, where the body’s immune system mistakenly attacks its own tissues, are fundamentally connected to chronic inflammation and are often triggered by gut microbiome imbalances. Inflammation is not just a symptom but the underlying mechanism driving these diseases. Research consistently points to a dysfunctional or altered microbiome as one of the most critical factors in the onset and progression of autoimmune conditions. The microbiome, which orchestrates the health of the immune system and integrates all bodily systems, is central to maintaining this delicate balance. The primary function of the immune system is to defend your body. However, autoimmune conditions cause your body to mistakenly attack healthy tissue, resulting in systemic inflammation. Inflammation is the root cause of several chronic conditions, and it can wreak havoc on healthy gut bacteria. Unfortunately, many routine tests can miss the common markers of inflammation and autoimmune conditions. Patients with autoimmune diseases often struggle with symptoms that include:

  • Fatigue and low energy
  • Joint and muscle pain
  • Malaise or generally feeling “ill” without a clear reason
  • Inflammation (swelling, redness, heat, or localized pain)
  • GI dysfunction or symptoms
  • Skin problems or rashes
  • Fever or swollen glands
  • Low thyroid function

The Role of Inflammation in Autoimmune Diseases

Chronic inflammation is a hallmark of autoimmune diseases. It is the process by which the immune system responds to perceived threats, but in the case of autoimmune diseases, this response is misdirected towards the body’s own tissues. Inflammation leads to the degradation of tissues and organs, manifesting in conditions like rheumatoid arthritis, lupus, and multiple sclerosis.

The Microbiome’s Influence on the Immune System

The microbiome plays a crucial role in regulating the immune system. It is responsible for maintaining immune homeostasis, ensuring that the immune system is neither overactive (leading to autoimmunity) nor underactive (leading to infections). A healthy microbiome is diverse, with a wide variety of bacterial species that contribute to the immune system’s proper functioning. However, when the microbiome becomes imbalanced—a condition known as dysbiosis—this equilibrium is disrupted. Dysbiosis is characterized by reduced diversity and an overgrowth of certain harmful bacteria, which can lead to increased intestinal permeability (“leaky gut”). This allows bacterial endotoxins to enter the bloodstream, triggering systemic inflammation and contributing to the development of autoimmune diseases.

Benefits of Autoimmune Disease Treatments

Autoimmune disease treatments can reduce your symptoms, increase your energy, and slow the progression of different types of conditions. Dr. Kellman can determine the best protocol and personalize your treatment to support your gut microbiome. He can combine therapeutic modalities for:

  • Enhanced quality of life: He can reduce inflammation and fatigue for improved quality of life and fewer symptoms.
  • Preventing disease progression: He can prevent the disease from becoming worse with lifestyle modifications that support your immune system.
  • Improving physical performance: If you struggle with chronic pain, he can alleviate it with targeted treatments to improve your daily function.
  • Enhancing mental clarity: Managing your symptoms and pain can improve your mental clarity, especially if you are living with the stress of chronic pain and inflammation.
  • Customizable treatments: He can take a multidisciplinary approach to create a unique treatment plan for your needs.

Peptide Therapy

Peptides are small proteins. Your body naturally produces these short chains of amino acids that act as signaling molecules used to stimulate hormone production and prompt immune responses that can help the body fight against bacteria, viruses, and other diseases. They also help your body repair damaged tissue. For patients with a compromised gut microbiome, Dr. Kellman can use peptide therapy to improve immune function. Many peptides are FDA-approved and peptide therapy is backed by a breadth of scientific research. These naturally occurring peptides have been proven to be both safe and effective, with few, if any side effects. Overwhelmingly patients have seen significant benefits through the use of peptide therapy, and it can be extremely beneficial for many autoimmune conditions.

Stem Cell & Exosome Therapy

Stem cell therapy is one of the most common and well-known areas of regenerative medicine. Exosomes have also shown tremendous success in rebalancing the gut microbiome and helping patients find relief from autoimmune conditions. Exosomes from young stem cells produce growth factors, which aid in the modulation of an overactive immune system, thereby stimulating it to function properly. Exosomes provide an even greater positive effect by harnessing the power of these growth factors. The cell line that we source our exosomes from contains 300+ growth factors to support your gut.

Autoimmune conditions can result in damage to body tissue, which can adversely affect a patient’s quality of life. The use of exosomes, either by themselves, or in conjunction with stem cell therapy, has been shown to successfully stimulate the regeneration of tissue, control inflammation, aid in the modulation of the immune system, and support the digestive system.

Low Dose Naltrexone

Low-dose naltrexone (LDN) is a drug used to treat opioid addiction. However, when used in very low doses, it can boost endorphins (which are usually low in people with autoimmune conditions) help modulate the immune system, and rebalance the gut. Studies have shown that LDN can have powerful anti-inflammatory effects, which can be especially beneficial for people suffering from Hashimoto’s thyroiditis or other autoimmune conditions.

Rebalancing the Gut Microbiome With Targeted Nutritional Therapy

Herb nootropics, specific strains of probiotics and nutraceuticals, are a type of nutritional therapy we can use to help reduce the symptoms of autoimmune conditions. Probiotics are essential for healing and balancing the gut microbiome. Depending on your symptoms, we can adjust your diet to include probiotic-rich food or prescribe a targeted set of probiotic strains that have been proven to help patients manage autoimmune conditions. Some strains of probiotics such as bifidobacterium, lactobacillus, and saccharomyces boulardii are beneficial for supporting the function of the digestive system. Saccharomyces boulardii is well-known for its anti-inflammatory properties and for its ability to promote intestinal function. If you suffer from a “leaky gut,” it can help your body repair damaged intestinal mucus membranes to optimize your digestive health.

What Short Chain Fatty Acids Can Do For the Gut

With saccharomyces boulardii, we can restore the short-chained fatty acids (SCFA) balance in the gut. Short Chain Fatty Acids (SCFAs) are crucial to gut health and in the treatment of autoimmune conditions. The main food component that impacts the gut microbiome composition and activity is fiber. The bacteria in our gut can ferment this fiber, resulting in the production of SCFAs (acetate, propionate, and butyrate) which have recognized health-promoting activities such as reducing inflammation, rebalancing the gut microbiome, and improving immune system function.

Butyrate is the main energy source for colonocytes, the cells that make up your gut lining. Higher levels of butyrate in the gut also help to boost antioxidant levels, which protect against free radicals. All of these things protect the GI tract, improve digestion, and reduce overall inflammation. Saccharomyces boulardii also aids in boosting butyrate levels in the gut to promote further healing. Other key supplements include:

  • Turmeric, which is a natural anti-inflammatory agent
  • L-glutamine which promotes the healing of the gut
  • Vitamin D which aids in balancing and strengthening the immune system. Deficiencies in Vitamin D have also been limited to several chronic conditions, including autoimmune conditions.

Diet and Lifestyle

Dietary changes are an essential part of Dr. Kellman’s holistic approach to chronic conditions. When supporting the gut microbiome, it is important to address chronic inflammation at the root. For autoimmune conditions. Dr. Kellman’s anti-inflammatory Microbiome Diet includes supportive, functional nutrients and is personalized to your unique dietary needs to balance your microbiome and help restore your digestive function. You may also need to make lifestyle changes such as participating in exercises that help you reduce stress and sleeping regularly.

Dr. Kellman’s Microbiome-Centered Approach

Dr. Raphael Kellman is a pioneer in understanding the intricate relationship between the microbiome and the immune system. His approach involves restoring microbiome balance as the first line of defense against autoimmune diseases. This strategy includes:

  1. Comprehensive Microbiome Testing: Similar to genetic analysis, microbiome testing maps the specific bacterial species present in an individual’s gut. This allows for the identification of bacteria associated with autoimmune disorders. For instance, studies have shown that certain bacteria like Bacteroides fragilis can modulate immune responses, while others like Escherichia coli can exacerbate inflammation.
  2. Targeted Use of Probiotics and Prebiotics: Dr. Kellman emphasizes the use of specific probiotics that are known to reduce inflammation. For example, Lactobacillus rhamnosus has been shown to enhance the integrity of the gut barrier, thereby reducing systemic inflammation. Prebiotics, which are fibers that feed beneficial bacteria, are also crucial. These include inulin and fructooligosaccharides (FOS), which support the growth of anti-inflammatory bacteria like bifidobacterium.
  3. Herbal and Nutraceutical Interventions: Dr. Kellman employs herbs and compounds such as BPC-157, a peptide with strong anti-inflammatory properties, to specifically target inflammatory pathways involved in autoimmune diseases. Research supports the use of BPC-157 in promoting gut healing and reducing inflammatory markers in autoimmune conditions.

Studies Supporting Microbiome-Immune Interactions

Several studies highlight the connection between the microbiome and autoimmune diseases:

  • A study published in Nature Communications (2020) found that individuals with autoimmune diseases like lupus had significantly altered gut microbiota, with reduced diversity and increased levels of pro-inflammatory bacteria.
  • Research from the Journal of Autoimmunity (2018) showed that restoring gut microbiome balance in patients with rheumatoid arthritis led to reduced disease activity and inflammation.
  • A landmark study in Cell Metabolism (2019) demonstrated that the microbiome directly influences the production of key immune-regulating molecules like T-regulatory cells, which are critical for preventing autoimmune responses.

Reversing Autoimmune Disease through Microbiome Renewal

Dr. Kellman’s approach, known as the Microbiome Renewal Program, aims to restore the microbiome’s balance and diversity, thus resetting the immune system. This program involves strategic probiotic therapy – using specific strains of probiotics that are shown to suppress inflammatory cytokines, such as IL-6 and TNF-alpha, which are often elevated. If you are struggling with symptoms of an autoimmune condition but have not been diagnosed with one, comprehensive testing is available at Medicine of Tomorrow to improve your well-being and manage your symptoms. Contact our office at (212) 717-1118 to learn more about how autoimmune disease treatments can improve your figure.

Candidates

Ideal candidates for autoimmune disease treatments wish to support their bodies and reduce symptoms such as fatigue, low energy, muscle pain, malaise, and inflammation. The best candidates are nonsmokers who are prepared to lead a healthy lifestyle with regular exercise and a well-rounded diet. Suitable candidates:

  • Have been diagnosed with an autoimmune condition or have symptoms
  • Wish to reduce their symptoms for improved quality of life
  • Have realistic expectations about what we can achieve with the treatment
  • Are prepared to make lifestyle modifications for a healthier routine

We can discuss your medical history to determine which treatment you are the best candidate for to reduce your symptoms.

Autoimmune Testing Consultation

During your consultation, Dr. Kellman will discuss your symptoms and may perform a physical exam. Please come prepared to discuss your goals and expectations for your treatment. Autoimmune diseases are commonly missed via routine testing; therefore, it is not uncommon for people to suffer for an extended period with persistent, non-specific symptoms before being accurately diagnosed.

Common Triggers

Common triggers include:

  • Viral and bacterial infections
  • Exposure to toxins
  • Stress and anxiety
  • Food sensitivities
  • Gut microbiome imbalances and GI dysfunction, including “leaky gut” syndrome
  • Certain medications (especially excessive use of antibiotics)
  • Poor nutrition (particularly excessive intake of pro-inflammatory foods)
  • Genetics

Testing & Treatment Approach

By looking deeper, we can find the underlying causes, which allows us to treat them at the root level. Rather than simply treating symptoms, understanding the underlying mechanisms and triggers for your autoimmune condition allows us to resolve not only the symptoms but the underlying reason for it.

Systemic Inflammation

Systemic inflammation is at the heart of not only autoimmune conditions but other chronic diseases. Dr. Kellman uses highly specialized lab testing to identify common markers of inflammation such as CRP Interleukin 6 IL-8, IL-10, and TNF. He also assesses antioxidant levels to determine one’s true immune function and inflammation, which are also markers of autoimmunity.

Gut Health and Autoimmune Disease

Dr. Kellman also tests gut function and microbiome health. One of Dr. Kellman’s groundbreaking contributions to the field of autoimmunity is understanding that if you have an autoimmune disease, chances are high that you also have a thyroid condition— even if routine tests show normal thyroid results. This connection could explain many symptoms one might be experiencing.

Cost of Autoimmune Disease Treatments in New York City

The cost of your autoimmune disease treatment will depend on your condition and the severity of your symptoms. During your consultation, we can provide a quote based on the type of treatment you need to help you feel your best. Contact our office or call (212) 717-1118 to learn more about how we can help you restore your energy and well-being. Contact our New York office or call (212) 717-1118 to learn more.

FAQ

How long does an autoimmune disease treatment take to rebalance my gut?

The length of your treatment will depend on your symptoms and the severity of your condition. Patients who are consistent with lifestyle changes often see the best results.

Can stress trigger autoimmune disease and gut microbiome imbalances?

Stress can exacerbate the symptoms of your autoimmune disease. We can discuss lifestyle modifications such as stress reduction techniques to help you feel your best.

How do I know if an autoimmune disease treatment is right for me?

If you have been diagnosed with an autoimmune disease in the past or you are struggling with common symptoms of an autoimmune disease, we can perform testing or treat your symptoms.

References

  1. Rosenblum MD, Gratz IK, Paw JS, Abbas AK. Treating Human Autoimmunity: Current Practice and Future Prospects. Science Translational Medicine. 2012;4(125):125sr1-125sr1. doi:https://doi.org/10.1126/scitranslmed.3003504
  2. Fairweather D, Rose NR. Women and Autoimmune Diseases. Emerging Infectious Diseases. 2004;10(11):2005-2011. doi:https://doi.org/10.3201/eid1011.040367
  3. Autoimmune Diseases. National Institute of Environmental Health Sciences. Accessed January 2, 2024. https://www.niehs.nih.gov/health/topics/conditions/autoimmune#:~:text=Scientists%20know%20about%20more%20than